The Effect of Interleukin-2 -330 T/G Polymorphism in People with Schizophrenia Among The Batak and Javanese Ethnic Groups.

Background: Schizophrenia is a complex disorder involving multiple genes with mild to moderate effects and non-genetic risk factors such as environmental and psychological influences that alter brain chemistry. Significant reduction in interleukin-2 production by peripheral lymphocytes is an immunological finding replicated in schizophrenia across various countries. Investigations on the interleukin-2 -330 T/G polymorphism in people with schizophrenia (PWS) are still minimal, and the study location involves only a few countries with different results. Therefore, this study aims to examine the effect of interleukin-2 -330 T/G polymorphisms in people with schizophrenia among the Batak and Javanese ethnic groups in Indonesia, particularly in North Sumatra. Method: This study used purposive non-probability sampling to recruit people with schizophrenia with 120 Batak and 120 Javanese subjects who were hospitalized at Prof. M. Ildrem Mental Hospital, Medan, Indonesia. The interleukin-2 -330 T/G polymorphism was examined by the PCR method. Result: The results showed that the genotype frequency of the Batak people with schizophrenia is as follows: GG 11.7%, TG 53.3% and TT 35%. Furthermore, the group of Javanese people with schizophrenia is as follows: GG 23.3%, TG 44.2% and TT 32.5%. The OR for the genotypic comparison of GG was found to be 2.154 with 95% CI 0.992-4.678, p=0.053, while that of the TG genotype was 0.892 with 95% CI 0.505-1.574 and p=0.693. The T allele was higher than the G allele in Batak and Javanese ethnic groups, as demonstrated by p=0.713, OR=0.919 with 95% CI 0.641-1.318. Conclusion: There is no statistically significant difference between the occurrence frequency of alleles. In addition, there is no significant relationship between the GG and the TG genotype of the interleukin-2 - 330T/G polymorphism in people with schizophrenia among the Batak and the Javanese ethnic groups.

Correlation Between Schizophrenia and Coronavirus Disease in North Sumatera, Indonesia: A Correlative Analytical Study.

Background: In the first quarter of 2020, two cases of coronavirus disease (COVID-19) were reported in Indonesia, approximately 4 months after the first case was reported in China. The numbers continued to increase following the introduction of many variants of the virus. The pandemic may have an impact on the community's mental health, particularly on those with mental illnesses. Therefore, this study aimed to determine the correlation between schizophrenia and COVID-19 based on demographic characteristics. Methods: This nominal-nominal and numerical-nominal correlative analytical study used a cross-sectional approach and was conducted at a psychiatric hospital in North Sumatra. The sample population consisted of 48 patients and 48 healthy controls, who were selected using a non-probability consecutive sampling method. Results: The analysis showed that there were correlations between schizophrenia and COVID-19 (r = 0.417, p < 0.001) and between the age of patients with schizophrenia and COVID-19 with (r = 0.544). Conclusions: COVID-19 is correlated with schizophrenia and the age of patients with schizophrenia. We recommend that patients with schizophrenia follow the same health guidelines as the clinical high-risk group for COVID-19 and receive the same treatment. Physicians that treat patients with COVID-19 should pay close attention to those with schizophrenia because they may underestimate their condition.

The Difference between Hospital Anxiety and Depression Scale - Anxiety Scores in Batak Male and Female with Schizophrenia: Preliminary Study.

INTRODUCTION: Anxiety disorders can be comorbid with schizophrenia. There was 38.3% of subjects with schizophrenia spectrum disorders suffer from at least one anxiety disorder. In the general population, it was found that higher levels of anxiety were experienced by women than men. AIM: To measure the difference between Hospital Anxiety and Depression Scale-Anxiety (HADS-A) scores in Batak male and female with schizophrenia. MATERIAL AND METHODS: This preliminary study was a comparative analytical study with a cross-sectional approach involving twenty participants, divided into two groups, Batak male and female in the stabilisation phase who was outpatient in Prof. Dr M. Ildrem Mental Hospital Medan. Patient with schizophrenia was filled questionnaire of HADS-A to measure score of anxiety. RESULTS: There was no statistically significant difference of HADS-A score from Batak male and female with schizophrenia with p-value 0.129. CONCLUSION: From this preliminary study we found that there was no statistically significant of HADS-A scores in Batak male and female with schizophrenia maybe because of stabilisation phase whereas patients have got treatment, so the scores of anxieties have decreased.

The Comparison of Hospital Anxiety and Depression Scale-Anxiety Scores between Female Caregivers of People with Schizophrenia According to Gender Difference.

BACKGROUND: Caregiver plays an important role for a better outcome in people with schizophrenia, although it usually causes emotional distress for the caregiver. Anxiety is one of the emotional distress. Gender of schizophrenic patients is associated with the emotional distress of caregiver. The differences in HADS-A scores between female caregivers of people with schizophrenia according to gender in Indonesia remain unclear. AIM: To determine whether HADS-A scores are higher in a male group compare with the female group. METHODS: This study was an analytical study with a cross-sectional approach to determine the comparison of HADS-A score between 27 female caregivers of male schizophrenic patients (male group) and 27 female caregivers of female schizophrenic patients (female group) in Prof. Dr M. Ildrem Mental Hospital Medan, using a HADS rating scale. RESULTS: There is no difference between the male and female group in caregivers age, marital status, employment status, family income/month, education time, the relationship with people with schizophrenia, caring time, time spent / weeks, and the patients age, employment status, education time, PANSS score and number of relapses. The comparison between total HADS-A score between the male group and the female group is not significant with 9.52 ± 4.90 v 8.70 ± 4.49 (p = 0.53). CONCLUSION: HADS-A scores are not higher in caregivers of male with schizophrenia compared with caregivers of a female with schizophrenia.

Shared Psychotic Disorder (Folie À Deux): A Rare Case with Dissociative Trance Disorder That Can Be Induced.

BACKGROUND: Shared psychotic disorder was first introduced in the 19th century in France with the name Folie à deux. Since then, the concept of Folie à deux has been developed and produces several subtypes in France. In DSM, this disorder is called Shared Psychotic Disorder, and in ICD-10, it is called Induced Delusional Disorder. However, some of the classic subtypes of Folie à deux are not included in the above categories. CASE REPORT: We found a case of shared psychotic disorder between a 38-year-old male inducer, a Batak tribe with two female recipients, 34 and 36 years from the Batak tribe. They were found to share the same delusions and hallucinations, and inducers could make recipients into trance conditions. These three individuals did not get along with the surrounding community and often carried out activities and perform rituals together. CONCLUSION: Overall, our case has some unique features of folie à deux. In this case, there is a trance condition that can be induced that have not been reported in the literature or case reports related to Folie à deux.

Differences in Total Score of Positive and Negative Syndrome Scale between Bataknese and Javanese Men with Schizophrenia Receiving Risperidone Treatment.

BACKGROUND: Schizophrenia is a psychopathological syndrome clinic involving cognition, emotion, perception and other aspects from the individual which interferences. This interference is normally started before age 25, and it can affect all social classes. AIM: To find out the difference in total positive and negative syndrome scale (PANSS) scores in schizophrenia between Bataknese and Javanese who have received treatment with risperidone. METHODS: This study is a prospective study. This study used numeric comparative analytic two unpaired groups to observe the differences of PANSS score of the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment. RESULTS: Our study found that the average score of PANSS for Bataknese was 49.76 ± 12.65 and Javanese was 42.43 ± 9.05. CONCLUSION: There was a difference score of PANSS for the man with schizophrenia between Bataknese and Javanese who had received risperidone treatment for 6 weeks (p = 0.037).

Brain-Derived Neurotropic Factor Serum Level and Severity Symptom of Bataknese Male Patients with Schizophrenia in North Sumatera, Indonesia.

BACKGROUND: Schizophrenia is a severe mental disorder that is multi-causative and multi-factor, generally affecting about 1% of the population. The elevation level of brain-derived neurotrophic factor (BDNF) offers several protections from other neurodegenerative processes that occur in schizophrenia since this deficit of neurotrophic factors can contribute to changes in brain structure and function that underlie the schizophrenia psychopathology. AIM: To analyse the correlation between BDNF serum levels and symptom severity by using the Positive and Negative Syndrome Scale (PANSS) instrument in Bataknese male patients with schizophrenia. METHODS: This study was a correlative analytical study with a cross-sectional approach using the Positive and Negative Syndrome Scale (PANSS) instrument to assess symptom severity with 60 subjects of Bataknese male patients with chronic schizophrenia. Moreover, this research was conducted at the Psychiatric Hospital of Prof. Dr M. Ildrem Medan, Indonesia. BDNF serum was analysed with the Quantitative sandwich enzyme immunoassay technique by via Quantikine ELISA Human CXCL8/IL-8 HS. Also, the data analysis was performed through Spearman's correlative bivariate analytics using SPSS software. RESULTS: A negative correlation between the BDNF serum level and the negative scale PANSS score in men with schizophrenia (r = -0.820, p < 0.001) was found. Moreover, there is a negative correlation between BDNF serum levels and PANSS total scores in men with schizophrenia (r = -0.648, p < 0.001). CONCLUSION: BDNF serum level in Bataknese male patients with schizophrenia has a relationship that affects the severity of symptoms in schizophrenic patients, especially for negative symptoms.

Affective Psychopathology Towards the Quality of Life of Breast Cancer Patients with Radiotherapy in Medan, Indonesia.

BACKGROUND: Cancer has to become the scariest disease and tends to reduce the quality of life of the patient. Therefore, it is not only a medical treatment that needs to be conducted but also a psychological treatment. AIM: to analyse the relationship between affective psychopathology and the quality of life of breast cancer patients who are receiving radiotherapy treatment. METHODS: This research was a correlative analytical study with a cross-sectional approach using the Hospital Anxiety and Depression Scale (HADS) instrument to assess psychopathological features and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) to determine the quality of life. This research was conducted in March 2016-July 2016 at Vina Estetika Cancer Center Hospital, Medan, Indonesia. As many as 47 subjects were divided into two criteria; Inclusion criteria, participants with breast cancer who were undergoing radiotherapy, aged over 18 years, with HADS score ≥ 17, and the exclusion criteria, were patients suffering from chronic psychiatry diseases. RESULTS: Affective psychopathology was indicated to result in a significant negative correlation with the quality of life of breast cancer patients which whom were treated with radiotherapy with p = 0.035 and r = -0.267. This suggests that with a higher HADS, a decrease in quality of life will occur. CONCLUSIONS: Affective psychopathological comorbidities have a great influence on the quality of life of patients who are undergoing radiotherapy. Thus, cancer management must include screening for psychopathological morbidity. Moreover, psychological rehabilitation must also be provided along with the cancer treatment.

Sociological and Psychological Factors on Prohibited Substances Abuse in Rehabilitation Centre of Medan City, Indonesia.

INTRODUCTION: Prohibited substances issue and their abuse have become a scourge for people in Indonesia. This situation creates concern for every level of society since this is very influential to damage and can even eliminate generations at a later time. AIM: This study aims to determine the characteristics of age, education, psychological and social problems related to substance dependence experienced by individuals with substance disorders who undergo rehabilitation in Medan, Indonesia. METHODS: This study is a cross-sectional analytic, in which the sample of this study was individuals who underwent rehabilitation in the Rehabilitation Center in Medan City who fulfilled the inclusion and exclusion criteria. A structured interview was carried out with the MINI ICD-10 on part M. disorders related to psychoactive substances. Furthermore, to see the level of dependence, WHO ASSIST questionnaire (The Alcohol, Smoking and Substance Involvement Screening Test) was used. RESULTS: This study discovered that subjects with age above 21 years were the most dominant of the prohibited substance users group as many as 87 people (69%), Batak tribe with 73 people (57.9%), residence originating from outside the city with 70 people (55.6%), Unmarried with 87 people (70.2%), education level is medium (junior high school) with 117 people (92.9%) and work as many as 77 people (61.1%). The study also found that the most dominant number of prohibited substances users were single users of methamphetamine and a combination of two substances, each of which was 49 people (38.9%). There is no relationship between social factors and patterns of prohibited substance use. Also, the most dominant users of prohibited substances who undergo rehabilitation are those based on family and police (involuntary admission). Finally, as many as 70 people used methamphetamine require intensive intervention. CONCLUSION: This study shows that social and demographic factors are not related to the pattern of prohibited substance use.

Indonesian Version of Addiction Rating Scale of Smartphone Usage Adapted from Smartphone Addiction Scale-Short Version (SAS-SV) In Junior High School.

BACKGROUND: The increase of smartphone user among Indonesian junior high school students, particularly for teenagers, indicates the addiction factor of the smartphone. AIM: This research is designed to adapt the Smartphone Addiction Scale-Short Version (SASS-SV) to Indonesian version based on cultural adaptation of the rating scale. METHODS: This study involves 300 participants consisted of 151 of male children and 149 female children with an average age is 13.27 years-of-old. The validity of concurrent was used to obtain the validity, while the internal consistency and Receiver Operating Characteristic (ROC) were conducted to confirm the reliability of the rating scale. RESULTS: In purpose to measure internal consistency, the Cronbach alpha has been applied. The Cronbach alpha value was 0.740, and Concurrent validity was checked to NMP the Nomophobia Questionnaire (NMP-Q) based on Indonesian version. The analysis of ROC showed that the value of Area under the Curve (AUC) was 0.997 (0.990-1.000), with cut-off value accounted for ≥ 32, a sensitivity value of 0.91 and specificity value was 0.973 for the male children. On the hand of female children, the results showed similarity with the AUC was 0.996 (0.998-1.000), and the cut-off, sensitivity and specificity values were accounted for ≥ 34, 0.91, and 0.974 respectively. CONCLUSION: The Indonesian version of SAS-SV provided acceptable validation results as well as the reliability, and this version can be used to evaluate the smartphone addiction in Indonesia.